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KMID : 0942820070060020073
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Journal of Korean Brain Tumor Society
2007 Volume.6 No. 2 p.73 ~ p.79
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Immunotherapeutic strategies for glioblastoma
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Yun Mi-Jung
Han Sang-Bae
Nam Do-Hyun
Kim Choong-Hyun
Kim Jeong-Hoon
Choi Jong-Sung
Kim Hwan-Mook
Lim Jae-Seung
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Abstract
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Despite efforts and advances in surgical resection, radiation, and chemotherapy, the mean survival time of glioblastoma remained little changed during the last few decades. To overcome this situation, immune cell therapy has been attempted in various animal models and human cancer patients. Immunotherapy for glioblastoma aims at enhancing immunogenicity of glioma cells and cytotoxic activity of immune effector cells. The present review focuses on immune-mediated treatment approaches for glioblastoma and therapeutic trials. Especially, we address the usefulness of cytokine-induced killer cells(CIK cells) for treatment of glioblastoma patients.
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KEYWORD
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Glioblastoma·Immune cell therapy, Cytokine-induced killer(CIK) cells
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